A novel mouse model for an inducible gene modification in the renal thick ascending limb
American Journal of Physiology-renal Physiology(2023)
摘要
The renal thick ascending limb (TAL) is critical for renal control of fluid and ion homeostasis. However, the underlying molecular mechanisms that regulate TAL function are incompletely understood. This study describes a novel transgenic mouse model (Slc12a1-creERT2) for inducible and highly efficient gene targeting in the TAL that promises to ease physiological studies on the functional role of candidate regulatory genes.
更多查看译文
关键词
inducible gene modification,novel mouse model,mouse model
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要