Synthesis and Characterization of Tadalafil Nanoparticles by Hydrothermal Method

Abstract Tadalafil (TDFL) nanocrystals, a weakly water-soluble medication, were effectively produced using a hydrothermal method to improve solubility and dissolving rate. Tween 80 was chosen as an effective surfactant for inhibiting aggregation during the stabilization of medication nanocrystals. Under ideal circumstances, nearly spherical nanocrystals with a mean particle size of 284 nm were produced. The FTIR study revealed that the precipitated nanoparticles had the same chemical structure as the raw TDFL, and scanning electron microscopy (SEM) revealed that the TDFL Nano agglomerates. When compared to the unprocessed medication, differential scanning calorimetry (DSC) analysis revealed no significant crystalline alteration in the nanocrystals. Furthermore, as compared to the raw material, the dissolution rate of the processed TDFL nanocrystals in 120 minutes was considerably higher. As a result, it was determined that hydrothermal might be a straightforward and effective approach for producing poorly water-soluble drug particles with reduced particle size, narrow particle size distribution, and increased dissolving characteristics. The current work presents a forthright technique for synthesizing and scheming nanosized TDFL for improved drug delivery applications that do not require the use of organic solvents, is green, and has a high yield as a single-step procedure.