Rapid Peripheral Nerve Imaging by Fluorescent Polymer Dots for Minimizing the Risk of Intraoperative Nerve Injury

The cover feature illustrates the application of high-brightness green fluorescent polymer dots (Pdots) to intraoperative neuroimaging to achieve excellent tracing effects. Through direct administration, Pdots can rapidly bind to the epineurium and perineurium, stably characterizing the peripheral nerve. In addition, it was found that Pdots bind to nerve membranes, do not invade nerve cells, and have high biosafety. Our study illustrates that Pdots has the potential as a neurotracer in image-guided surgery and has significant implications for reducing iatrogenic nerve injury and related surgical complications. More information can be found in the Research Article by Liqin Xiong and co-workers.