Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2‐Mediated Unfolded Protein Reaction Activation (Adv. Healthcare Mater. 26/2023)

Hong‐Wen Liu, Lei Xu,Yiyang Zhang, Youmei Xie,Lishan Wang, Yifeng Zhou,Zhangding Wang, Yani Pan, Wenying Li, Lei Xu, Xinping Xu, Ting Wang, Ke Meng, Jianlin He,Yudong Qiu,Guifang Xu, Weihong Ge,Ye Zhu,Lei Wang

Advanced Healthcare Materials（2023）

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摘要

Chemotherapy Resistance Chemotherapy resistance is a big problem in treating cancer. In article 2300913, Yun Zhu, Lei Wang, and co-workers develop CuET-Lipid@Cela, in which copper inhibits Cela-induced UPR activation by reducing the translation efficiency of GRP78/BiP and find that the TMX2 gene may play an important role. Combination therapy is effective in a mouse model of CCA. The results highlight the potential of CuET targeting the TMX2/GRP78/BiP axis to overcome chemotherapeutic resistance in CCA.

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关键词

cholangiocarcinoma cells,unfolded protein reaction activation,copper,tripterine

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