Probiotic, Paraprobiotic, and Postbiotic as an Alternative to Antibiotic Therapy for Lactococcosis in Aquaculture

Studies describing antagonistic activity and disease resistance efficacy of potential probiotics towards lactococcosis caused by Lactococcus garvieae, Lactococcus lactis, Lactococcus piscium, and Lactococcus raffinolactis are limited. Most studies have focused on lactic acid bacteria (LAB), and less attention has been paid to Bacillus probiotics or other gram-positive or gram-negative members. Lactobacillus, Lactococcus, Leuconostoc, and Enterococcus are the most common genera of LAB tested towards L. garvieae either in in vitro or in vivo assays, and the obtained results are promising. Although strains of Flavobacterium, Pseudomonas, Aeromonas, and Vibrio genera have shown antibacterial activity against L. garvieae, further work is required to confirm such inhibition activity, particularly by disease resistance bioassays. recently, gram-positive or gram-negative bacteria strains have demonstrated antimicrobial inhibition towards L. garvieae in postbiotics, but details of their mode of action warranted further studies. This review addresses the probiotic therapy for lactococcosis in aquaculture and discusses the present gaps.