A Ferroptosis-Related Prognostic Model of Mantle Cell Lymphoma

Abstract Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin's lymphoma. Ferroptosis, an iron-dependent programmed cell death, is closely related to cancer prognosis. In this study, we established a model of ferroptosis-related genes for prognostic evaluation of patients with MCL. Using the single-cell RNA sequencing datasets GSE184031 and GSE32018 from the Gene Expression Omnibus, we identified 139 ferroptosis-related genes in MCL. Next, a prognostic model was constructed by Cox regression and LASSO regression analysis. In our model, the prognosis of MCL patients was assessed by risk scoring using 7 genes ANXA1, IL1B, YBX1, CCND1, MS4A1, MFHAS1 and RILPL2. The patients were divided into high-risk and low-risk groups based on our model, and the high-risk patients had inferior overall survival. Finally, according to our model and computational drug sensitivity analysis, four small molecule compounds, BMS-754807, SB216763, Doramapimod and Trametinib, were identified as potential therapeutic agents for patients with MCL. In summary, we provide a prognostic model with ferroptosis-related gene signature for MCL.