Understanding correlation between diffusion MRI-derived white-matter organization and neuropsychological measures in Parkinson’s disease patients with freezing of gait

Background: The pathophysiology of freezing of gait (FoG) in Parkinson’s disease (PD) is incompletely understood. We hypothesized that a differential correlation between the white matter (WM) organizational change as measured using diffusion MRI (dMRI) and the neuropsychological measures will exist between PD-FoG+ and PD-FoG- patients.