Head-to-head comparison of [18F]-FDOPA PET and [123I]-FP-CIT SPECT for assessing nigrostriatal degeneration in patients with a clinically uncertain parkinsonian syndrome

Background: Two commonly used imaging techniques to aid in the diagnosis of neurodegenerative parkinsonian syndromes are single-photon emission computed tomography with [123I]-FP-CIT (DAT-SPECT) and positron emission tomography with [18F]-FDOPA (FDOPA-PET). We provide a unique series of parkinsonian patients who received both FDOPA-PET and DAT-SPECT in routine clinical practice and assess potential differences between these techniques.