Immunoexpression of twist in patients presenting with odontogenic keratocyst

Objectives: To evaluate the immunohistochemical expression of Twist in patients presenting withOdontogenic keratocyst.Materials and Methods: This study was performed at the department of Pathology, “KhyberMedical University Peshawar” from January 2022 to June 2022.A total of 83 patients meetingthe inclusion criteria were included. All the patients were diagnosed for OKC according to WHOcriteria.Twist immunoexpression of OKC blocks were peroformed according to IHC protocol.SPSS version 22 was used for the analysis of data.Results: Out of eighty three cases of Odontogenic keratocyst, 51 cases were positively stainedfor Twist (61.4%),while 32 cases were negatively stained (38.6%).Amongst the positively stainedcells 17 cases (20.5%) were mild positive,16 cases (19.3%) showed moderate immunopositvityand eighteen cases (21.7%) exhibited strong positivity for Twist.Conclusion: It is concluded that twist immunohistochemiacal analysis shows negative to strongpositive results in odontogenic keratocyst, suggesting its possible neoplastic nature.