The Successional Pattern of Microbial Communities and Critical Genes of Consortia Subsisting on Chloramphenicol and Its Metabolites Through Long-Term Domestication

•Three domesticated consortia could degrade CAP, PNB, and DCA with high efficiencies.•A successional pattern of the microbial community across domestication was revealed.•Collaboration of Sph., Cab., and Cup. contributed to a high CAP mineralization rate.•Dynamic changes in key genes involved in CAP, PNB and DCA metabolism were deciphered.•Carbon source and pH had significant impacts on the biodegradation efficiency of CAP.