Suppression of HIV in the first 12 months of antiretroviral therapy: a comparative analysis of dolutegravir- and efavirenz-based regimens

Highlights Viral suppression improved after introducing a dolutegravir-based regimen. HIV viral loads <50 copies/mL were lower than expected (<90%). Higher viral suppression was found when antiretroviral therapy adherence/alterations were controlled (per-protocol analysis). Some baseline characteristics can influence the effectiveness of first-line antiretroviral therapy. ABSTRACT Objective To compare viral suppression in treatment-naïve adults starting antiretroviral therapy with dolutegravir (50mg)- and efavirenz (600mg)-based regimens. Methods We analyzed secondary data from Brazilian health information systems of people living with human immunodeficiency virus who [...]