Frontispiece: Multifunctional Intrinsically Disordered Regions in Transcription Factors

Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular feedback mechanism that interfaces with the genome, consolidating information for transcriptional regulation. TFs consist of both structured DNA-binding domains and long intrinsically disordered regions (IDRs) embedded with motifs linked to transcriptional control. These IDRs endow transcription factors with structural plasticity which is central to their functions in the nucleus. More information can be found in the Review article by P. O. Heidarsson and co-workers. (DOI: 10.1002/chem.202203369)