Endoscopic electroporation in the treatment of a locally advanced colorectal cancer

Abstract Text Endoscopic electroporation is a novel technique used in the management of inoperable colorectal and oesophageal cancers. This technique involves the delivery of short electrical pulses to tumour tissues, which transiently increases cell membrane permeability, allowing the passage of calcium ions through the open pores to give a high local cytotoxic effect with minimal adverse systemic effect. In this video we show how this technique is used to treat an inoperable locally advanced obstructing sigmoid adenocarcinoma. Clinical result of this technique has shown excellent safety profile, tumour regression, and marked reduction or cessation of tumour bleeding [1] [2] [3] [4].