Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brain
bioRxiv (Cold Spring Harbor Laboratory)(2023)
摘要
ABSTRACT Using spatial transcriptomics and FISH, we detected very few cells expressing neural stem cell- and proliferation-specific genes in the human dentate gyrus (DG) from childhood to middle age. However, we observed at all ages a significant number of DG cells expressing the immature neuronal marker DCX . Across ages, the majority of these cells displayed an inhibitory phenotype, while the remainder were non-committed or excitatory in nature.
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关键词
adult hippocampal neurogenesis,spatial transcriptomic analysis,brain
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