Tumoral translocator protein expression is associated with microglia-related whole brain inflammation in glioblastoma

Laura M. Bartos,Stefanie Quach,Sabrina V. Kirchleitner,Jens Blobner, S. T. Kunte, P. Beumers, L. Hörmann,Karin Wind-Mark,Adrien Holzgreve,Peter Bartenstein,Jörg C. Tonn,Louisa von Baumgarten,Matthias Brendel, NL Albert

Nuklearmedizin-nuclear Medicine（2023）

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摘要

Ziel/Aim PET targeting the translocator protein (TSPO) emerged as an important tool for in vivo assessment of glioma and serves to detect microglial activation. In this regard, the presence of remote neuroinflammation in glioma is only sparsely understood. Thus, we used translational TSPO PET imaging to investigate whole brain inflammation in therapy naïve glioma.

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tumoral translocator protein expression,glioblastoma,whole brain inflammation,microglia-related

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