Specificity of 18_kDa translocator protein tracer retention in single cells and non-cellular compartments of experimental glioblastoma

Ziel/Aim TSPO PET imaging might facilitate monitoring of glioblastoma in preclinical models and patients. However, the detailed cellular and non-cellular sources of the TSPO PET signal in glioblastoma remain to be investigated. In this study, we used blocking by excessive cold ligand and subsequent cell sorting (scRadiotracing) to disentangle the magnitude of retained and blocked TSPO tracer in single cells and non-cellular compartments of glioblastoma.