Mechanical forces suppress antiviral innate immune responses from asthmatic airway epithelial cells following rhinovirus infection
American Journal of Physiology-lung Cellular and Molecular Physiology(2023)
摘要
Bronchoconstriction is the main physiological event in asthma, which leads to worsened clinical symptoms and generates mechanical stress within the airways. Virus infection is the primary cause of exacerbations in people with asthma, however, the impact of bronchoconstriction on host antiviral responses and viral replication is unknown. We developed two disease models, in vitro, and found suppressed IFN response from cells following the application of compression and RV-A1 infection. This explains why people with asthma have deficient IFN response.
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关键词
antiviral innate immune responses,rhinovirus infection,asthmatic airway,immune responses,mechanical forces
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