Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data

HomeStrokeVol. 54, No. 5Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplemental MaterialNo AccessResearch ArticleRequest AccessFull TextUnderstanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data Adam de Havenon, Aaron Bangad, Lesli E. Skolarus, Chad M. Aldridge, Robynne G. Braun, John W. Cole, Steven C. Cramer, Arne G. Lindgren, N. Abimbola Sunmonu, Bradford B. Worrall and Keith R. Lohse Adam de HavenonAdam de Havenon Correspondence to: Adam de Havenon, MD, Yale University, 15 York St, New Haven, CT 06510. Email E-mail Address: [email protected] https://orcid.org/0000-0001-8178-8597 Yale University, New Haven, CT (A.d.H., A.B.). Search for more papers by this author , Aaron BangadAaron Bangad https://orcid.org/0000-0002-0304-950X Yale University, New Haven, CT (A.d.H., A.B.). Search for more papers by this author , Lesli E. SkolarusLesli E. Skolarus https://orcid.org/0000-0002-3088-9838 Northwestern University, Evanston, IL (L.E.S.). Search for more papers by this author , Chad M. AldridgeChad M. Aldridge https://orcid.org/0000-0003-0539-9762 University of Virginia, Charlottesville (C.M.A., N.A.S., B.B.W.). Search for more papers by this author , Robynne G. BraunRobynne G. Braun https://orcid.org/0000-0002-3579-6665 University of Maryland, College Park (R.G.B.). Search for more papers by this author , John W. ColeJohn W. Cole https://orcid.org/0000-0001-9263-8930 Baltimore Veterans Affairs Medical Center and the University of Maryland (J.W.C.). Search for more papers by this author , Steven C. CramerSteven C. Cramer https://orcid.org/0000-0002-6214-6211 University of California, Los Angeles and California Rehabilitation Institute (S.C.C.). Search for more papers by this author , Arne G. LindgrenArne G. Lindgren https://orcid.org/0000-0003-1942-7330 Lund University, Sweden (A.G.L.). Search for more papers by this author , N. Abimbola SunmonuN. Abimbola Sunmonu University of Virginia, Charlottesville (C.M.A., N.A.S., B.B.W.). Search for more papers by this author , Bradford B. WorrallBradford B. Worrall https://orcid.org/0000-0001-9386-4091 University of Virginia, Charlottesville (C.M.A., N.A.S., B.B.W.). Search for more papers by this author and Keith R. LohseKeith R. Lohse https://orcid.org/0000-0002-7643-3887 Washington University School of Medicine in Saint Louis (K.R.L.). Search for more papers by this author Originally published10 Mar 2023https://doi.org/10.1161/STROKEAHA.122.042168Stroke. 2023;54:e201–e202"Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data." Stroke, 54(5), pp. e201–e202FootnotesThis article was sent to Liping Liu, Guest Editor, for review by expert referees, editorial decision, and final disposition.For Sources of Funding and Disclosures, see page e202.Supplemental Material is available at https://www.ahajournals.org/doi/suppl/10.1161/STROKEAHA.122.042168.Correspondence to: Adam de Havenon, MD, Yale University, 15 York St, New Haven, CT 06510. Email adam.dehavenon@yale.eduReferences1. Hughes RA, Heron J, Sterne JAC, Tilling K. Accounting for missing data in statistical analyses: multiple imputation is not always the answer.Int J Epidemiol. 2019; 48:1294–1304. doi: 10.1093/ije/dyz032CrossrefMedlineGoogle Scholar2. Thabane L, Mbuagbaw L, Zhang S, Samaan Z, Marcucci M, Ye C, Thabane M, Giangregorio L, Dennis B, Kosa D, et al. A tutorial on sensitivity analyses in clinical trials: the what, why, when and how.BMC Med Res Methodol. 2013; 13:92. doi: 10.1186/1471-2288-13-92CrossrefMedlineGoogle Scholar3. Yeatts SD, Martin RH. What is missing from my missing data plan?Stroke. 2015; 46:e130–e132. doi: 10.1161/STROKEAHA.115.007984LinkGoogle Scholar4. Fernandez-Ferro J, Schwamm LH, Descalzo MA, MacIsaac R, Lyden PD, Lees KR. Missing outcome data management in acute stroke trials testing iv thrombolytics. Is there risk of bias?Eur Stroke J. 2020; 5:148–154. doi: 10.1177/2396987320905457CrossrefGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails May 2023Vol 54, Issue 5 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/STROKEAHA.122.042168PMID: 36896708 Manuscript receivedNovember 29, 2022Manuscript acceptedJanuary 19, 2023Originally publishedMarch 10, 2023Manuscript revisedJanuary 4, 2023 Keywordsischemic strokealbuminodds ratiohyperglycemiaethnicityPDF download Advertisement SubjectsCerebrovascular Disease/StrokeClinical StudiesRace and Ethnicity