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Pan-Cancer Analysis of Copy-Number Features Identifies Recurrent Signatures and a Homologous Recombination Deficiency Biomarker to Predict Poly (ADP-Ribose) Polymerase Inhibitor Response

Jay A. Moore,Kuei-Ting Chen,Russell Madison,Justin Y. Newberg,Zoë Fleischmann,Shuoguo Wang,Radwa Sharaf,Karthikeyan Murugesan,Bernard J. Fendler,Jason D. Hughes,Alexa B. Schrock,Priti S. Hegde,Geoffrey R. Oxnard,David Fabrizio,Garrett M. Frampton,Emmanuel S. Antonarakis,Ethan S. Sokol,Dexter X. Jin

JCO precision oncology（2023）

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摘要
Analysis of 260K tumors IDs copy-number signatures and a HRD biomarker predictive of PARPi response.
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关键词
homologous recombination deficiency biomarker,poly,pan-cancer,copy-number,adp-ribose
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