Synthesis, Crystal Structures and Urease Inhibition of Copper(II) and Cobalt(III) Complexes Derived from (((2-(Pyrrolidin-1-yl)ethyl)imino)methyl)naphthalen-2-ol

Three copper(II) and cobalt(III) complexes, [CuL(dca)](n) (1), [CuL(N-3)](n) (2) and [CoL(N-3)(2)(DMF)] (3), where L is the monoanionic form of the Schiff base (((2-(pyrrolidin-1-yl)ethyl)imino)methyl)naphthalen-2-ol (HL), and dca is dicyanamide, have been prepared and characterized by elemental analyses, IR and UV-Vis spectroscopy, as well as single crystal X-ray diffraction. The Cu atoms in complexes 1 and 2 are in square pyramidal coordination, and the Co atom in complex 3 is in octahedral one. Complexes 1 and 2 inhibit the Jack bean urease with IC50 values of 0.25 +/- 0.14 and 0.32 +/- 0.15 mu mol L-1, respectively. Complex 3 show weak activity on Jack bean urease with percentage inhibition of 37%.