Arid1a mutation promotes cell proliferation and invasion, and leads to broad drug resistance in colorectal cancer

Feng Jin,Johannes Betge,Christoph Reißfelder, Lingjun Zhu,Sebastian Schölch

Zeitschrift Fur Gastroenterologie（2023）

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摘要

Introduction The ARID1A gene is mutated in approximately 10% of human colorectal cancers (CRC), and loss of function (LOF) is closely associated with CRC occurrence, progression, and poor prognosis. However, research on the clinical implications of ARID1A mutations is limited.

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arid1a mutation,colorectal cancer,drug resistance

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