An enhanced biophysical screening strategy to investigate the affinity of ASOs for their target RNA

Rouven Stulz, M. Lerche,Olivia Luige, Agnes Taylor,Stefan Geschwindner,Alice Ghidini

RSC chemical biology（2023）

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摘要

Benefits of early implementation of HT, inexpensive and enhanced biophysical screenings to investigate the affinity of ASOs for their target RNA using several biophysical techniques such as DSF, ITC, SPR, CD and SAXS.

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关键词

target rna,asos,enhanced biophysical screening strategy

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