Proton Therapy for Chondrosarcoma

Chondrosarcoma is a type of an endochondral bone malignancy which is primarily treated surgically with radiation therapy used in the adjuvant setting or in cases of unresectable disease. Proton therapy has potential advantages compared to traditional photon therapy for treatment of tumors in close proximity to critical structures due to the theoretic lower exit dose. Studies have shown improved survival in patients with skull base chondrosarcoma who undergo proton therapy. However, there is a lack of randomized data. Further studies are needed to define the role of proton therapy in treatment of skull base chondrosarcoma.