Cost-Comparison of Mechanical Thrombectomy and Catheter-Directed Thrombolysis in Intermediate-Risk Pulmonary Embolism

•Catheter-directed thrombolysis (CDT) and large-bore mechanical thrombectomy (MT) are the leading percutaneous-based therapies for intermediate-risk pulmonary embolism (PE).•Prior studies have demonstrated both treatments’ procedural safety and efficacy, but the financial implications of the interventions remain unclear.•This study aims to conduct a cost-benefit analysis to evaluate the economic advantages associated with CDT and MT from the perspective of the treating hospital.•This multicenter cost analysis does not reveal a distinct cost advantage between CDT and MT for intermediate-risk PE.•The observed cost differences were influenced by variations in practice patterns overtime and between institutions.