One-Pot Stereoselective Synthesis of Furantetrahydroquinoline Derivatives Using d/l-Ribose with a 2,3-O-Isopropylidene Group

Jilai Wu, S. Xie,Likai Zhou,Yixuan Liu, Yongjie Cui, Xiaoyan Huang,Chao Wei,Xiaoliu Li,Chunfang Zhang,Hua Chen

Journal of Organic Chemistry（2023）

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摘要

An efficient and convenient strategy has been successfully developed for the preparation of novel furantetrahydroquinoline derivatives using d/l-ribose with a 2,3-O-isopropylidene group through the aza-Diels-Alder mechanism. This method has high atom and step economy, high stereoselectivity, and gram-scale synthesis (yield 67%).

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关键词

furantetrahydroquinoline derivatives,stereoselective synthesis,one-pot

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