A Non‐G‐Quadruplex DNA Aptamer Targeting NCL for Diagnosis and Therapy in Bladder Cancer (Adv. Healthcare Mater. 20/2023)

DNA Aptamers Article 2300791 by Erxi Wu, Xiaoxiao Hu, and co-workers highlights the development of a non-G-quadruplex, nucleolin-targeting aptamer TB-5, which inhibits the invasion, migration, and proliferation of bladder cancer cells by disrupting mRNA transcription processes. TB-5 demonstrates potential as a diagnostic and therapeutic tool due to its high specificity and affinity for bladder cancer tissues, elucidating the significant role of nucleolin in bladder cancer pathology.