Origin of stronger binding of ionic pair (IP) inhibitor to Aβ42 than the equimolar neutral counterparts: synergy mechanism of IP in disrupting Aβ42 protofibril and inhibiting Aβ42 aggregation under two pH conditions

At pH 7.0, Aβ oligomer (AβP or AβF) acts as a galvanic battery for a dual inhibitor composed of a pair of positive and negative ions to exert an extraordinary inhibition/disaggregation effect on it by a unique synergistic mechanism.