Aquaporin 3 modulates the risk of death conferred by dehydration in COVID-19

Amanda Marks,Guillaume Butler‐Laporte,Satoshi Yoshiji,Tianyuan Lu, Dave R. Morrison,Teruyuki Nakanishi,Yiheng Chen,Vincenzo Forgetta,Yossi Farjoun,Robert Frithiof,Miklós Lipcsey,Hugo Zeberg,J. Brent Richards,Michael Hultström

Research Square (Research Square)（2023）

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摘要

Abstract Severe COVID-19 has been associated with dehydration. Recently, a genetic variant near the aquaporin 3 (AQP3) water channel was associated with severe COVID-19 (rs60840586:G, Odds Ratio: 1.07, P=2.5*10-9). We show that dehydration is associated COVID-19 mortality (OR = 2.06 [95% CI = 1.62-2.65], P = 9.13*10-9), and is modulated by interaction with rs60840586:G genotype (OR = 1.95 [95% CI = 1.22-3.28], P = 0.0075).

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dehydration

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