SPRR3 as a diagnostic and prognostic molecular marker for lung adenocarcinoma based on pan-cancer analysis

Abstract Proline-rich small repeat protein 3 (SPRR3) belongs to proline-rich protein family. For exploring SPRR3 expression and its prognostic value in various malignant tumors, we used multiple sets of biomedical information, especially SPRR3 gene level comparison within the pan-cancer. The different immune cell infiltration in pan-cancer is correlated with its specific biological function, molecular characteristics, diagnostic value and prognostic value. Meanwhile, this work further examined correlation between the SPRR3 expression in lung adenocarcinoma and the molecular biology function. Pan-cancer analysis results on 33 malignant tumors showed that SPRR3 was differentially expressed within diverse cancers, which predicted the dismal prognostic outcome of various malignant tumors. At the same time, SPRR3 is associated with immune infiltrating cells in lung adenocarcinoma. The ROC curve and survival curve suggested that SPRR3 had high accuracy in predicting cancer and may be the potential biomarkers used to diagnose and predict prognosis of cancer. Collectively, SPRR3 is the significant biomarker used to diagnose and predict pan-cancer prognosis. High SPRR3 expression independently predicted prognosis of lung adenocarcinoma, which may become a promising molecular cancer therapy target in the future.