Remote ischemic post-conditioning promotes reverse remodeling after pressure-overload myocardial hypertrophy

Abstract Remote Ischemic Post-conditioning (RIPostC) is a new type of endogenous cardiac protection that is applied widely in valvular heart surgery and coronary intervention. In this study, we demonstrated that RIPostC promotes postoperative reverse remodeling in rats with pressure overload cardiac hypertrophy by inhibiting cardiomyocyte apoptosis, interstitial fibrosis, and oxidative stress. RIPostC may initiate the endogenous protective mechanism of the heart by activating SIRT3, reduce the excessive apoptosis of cardiomyocyte and oxidative stress, thereby improving poor cardiac remodeling.