Supplementary Figure 1 from Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non–Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion

PDF file, 3170KB, (A) Schematic representation of the genomic region containing fig and ros1. Probes set 1 derived from ros1 (orange) and the deleted region (green). Probe set 2 derived from ros1 (orange) and fig (green). (B,C) Yellow arrows point to split signals indicative of balanced translocation in the HCC78 cell line and white arrows point to intact chromosome. (D,F) In both U-118 MG and tumor ID 749 only the ros1 (orange) probe anneals and the deleted region (green probe) does not. (E,G) ros1 (orange) and fig (green) probes overlap indicating fig-ros1 fusion. (H)