Chronic Anterior Skull Base Mucormycosis after COVID-19 Infection: Multidisciplinary Surgical Management and Reconstruction

Background: The ongoing COVID-19 epidemic has been responsible for wide-spread morbidity and mortality worldwide, with over 95 million cases and over 1 million deaths in the United States alone. An increasing amount of evidence has shown a connection between COVID-19 infection and development of rhino-orbito-cerebral mucormycosis (ROCM), including among patients with relatively mild COVID infection and/or no underlying risk factors. In this case report, we describe a patient without underlying risk factors who developed an atypical chronic presentation of mucormycosis involving the hard palate, paranasal sinuses and anterior skull base after COVID infection, and our multi-team approach to surgical resection and free flap reconstruction.