Qol-17. sleep quality dimensions in low and high-grade glioma survivors

Abstract In this study, we examined the relationship between sleep disturbance and tumor grades in a group of low-grade (LGG; grade I-II) and high-grade glioma (HGG; grade III-IV) survivors < 1 to 10+ years from initial diagnosis. 42 glioma survivors completed the Pittsburgh Sleep Quality Index (PSQI). We examined frequency of poor sleep quality (defined as PSQI >5) and compared global PSQI between LGG and HGG groups. We obtained high-resolution T1 weighted images from a subset of 24 patients for gray matter volume analyses. The sample was predominantly male (66%) and Caucasian (82%). Of the 42 participants, 31% (n = 13) had LGG and 69% (n = 29) had HGG. 60% (n = 25) of all participants had poor sleep quality, with no differences observed between LGG and HGG. There were no differences between groups in age, education, measures of depression and anxiety, or general health-related quality of life (MOS SF-36). A Mann-Whitney U test indicated that there was no significant difference in global PSQI scores between LGG (Mdn = 4) and HGG groups (Mdn = 6), U = 239, p = .254. Sleep quality was not associated with time since diagnosis for either LGG (r = .108, p = .724) and HGG groups (r=-.058, p = .762). Whole brain vertex-wise comparison revealed smaller gray matter volumes in patients with poor sleep quality versus good sleep quality in the isthmus cingulate, cuneus, and precuneus of the left hemisphere (p < 0.05). Our analyses suggest that sleep quality is important to assess in glioma survivors of any grade and at any time since diagnosis. Poor sleep in glioma survivorship could be associated with structural differences in brain regions sensitive to sleep problems in other populations. Given the high rate of sleep disturbance, further study is warranted to better understand risk and develop targeted interventions.