Amiodarone Pharmacovigilance Through an Intelligent Electronic Health Record Application.

Amiodarone is the most effective and commonly used antiarrhythmic medication. Given its risk of toxicity, routine monitoring is recommended but is challenging to ensure in clinical practice.We created an intelligent application, built within our electronic health record, that identified every living patient with an active outpatient prescription by a clinician in our health system. The application was designed to identify patients with lapses in recommended monitoring and facilitate scheduling of overdue testing.The percentage of patients with overdue monitoring tests decreased with use of the application, with greatest improvement in pulmonary function testing.Implementing a program to monitor and mitigate adverse reactions to amiodarone by using programable features of an electronic health record is feasible.