Removal of Microcystin-LR in lake water sample by hydrophilic mesoporous silica composites under high-throughput MALDI-TOF MS detection platform

Microcystins (MCs), a family of cyclic heptapeptide cyanotoxins, exists in aquatic environment where cyanobacterial bloom happens, which will accumulate in aquatic organisms and transfer through the food chain to higher trophic levels, posing a health risk to both animals and human bodies. Among various MCs, Microcystin-LR (MC-LR) is worthiest studied for its strong toxicity, ubiquity and widespread. Here in this work, iminodiacetic acid (IDA) decorated magnetic mesoporous silica (mSiO2) nanocomposites (Fe3O4 @mSiO2 -IDA) were facilely synthesized which possessed the merits of large surface area (188.21 m2/g), accessible porosity (2.66 nm), excellent hydrophilicity and rapid responsiveness to magnetic field. Then the composites were successfully employed to the removal process of Microcystin-LR in real water samples followed by Matrix -assisted laser desorption/ionization time -of -flight mass spectrometry (MALDI-TOF MS) analysis, achieving the removal efficiency above 92.5% even after ten recycles of the composites. It provided a potential method for removing MC-LR in aqueous environment with high effectiveness, lower costs and less secondary contamination. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.