Correlations of plasma angiopoietin-like 7, fetuin-A levels with coronary heart disease in patients with type 2 diabetes mellitus

Abstract Background: The prevalence of coronary heart disease (CHD) is higher in patients with type 2 diabetic mellitus (T2DM), however, relative parameters for evaluating T2DM patients with CHD are quite limited. Circulating angiopoietin-like 7（Angptl7）, fetuin-A（Fet-A） levels have all been found correlated with CHD and T2DM. Therefore, this study aimed to investigate the correlations of plasma Angptl7 and Fet-A levels with the CHD in patients with T2DM. Methods: T2DM patients were recruited and divided into diabetes without CHD group (T2DM, n=48) and diabetes with CHD group (T2DM+CHD, n=51) according to the history of CHD. Baseline data were collected. Plasma levels of Angptl7 and Fet-A were measured by enzyme-linked immunosorbent assay (ELISA) method. Results: Compared with that in T2DM patients, plasma Angptl7 levels in patients with T2DM+CHD were significantly increased，while the Fet-A levels and vitamin D levels were significantly decreased (P all<0.05). . Age, plasma level of Angptl7 and Fet-A were influence factors of occurrence of CHD in T2DM patients. Angptl7 and Fet-A possessed diagnostic value for T2DM patients with CHD, and the value was even higher when these two factors combined . Conclusions: Increased plasma Angptl7 and decreased plasma Fet-A levels are all linked with CHD in T2DM. The combination of Fet-A and Angptl7 possess better diagnostic value for CHD. Therefore, plasma Angptl7 and Fet-A might be promising for diagnosis of CHD in T2DM.