ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy (Adv. Healthcare Mater. 21/2023)

Wenjing Mo,Shujie Liu,Xiaozhi Zhao,Fayun Wei, Yuhang Li,Xinan Sheng,Wenmin Cao,Meng Ding, Wenlong Zhang,Xiaoqing Chen,Longxiyu Meng,Sheng Yao,Wenli Diao,Hui Wei,Hongqian Guo

Advanced Healthcare Materials（2023）

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摘要

Nanoenzymes In article 2300191 by Wenli Diao, Hui Wei, Hongqian Guo, and co-workers, a Zr-CeO nanozyme is developed to possess enhanced activities mimicking superoxide dismutase and catalase. Via scavenging intracellular reactive oxygen species, Zr-CeO exerts remarkable effects on diminishing myeloid-derived suppressor cells and M2-TAM immunosuppression simultaneously, and eventually boosts anti-tumor immune response and sensitizes tumor immunotherapy.

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sensitized cancer immunotherapy,cancer immunotherapy,ros

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