Bradykinin reduces proliferation and wound healing in primary endothelial cells

Introduction In the context of hereditary angioedema, acute swelling attacks occur due to highly elevated plasma levels of bradykinin. Although the concentration is increased permanently, patients just suffer swelling attacks intermittently. Thus, there must be additional triggers that ultimately lead to these swelling attacks, for example a mechanical damage of the endothelium. The subsequent healing of this could be impaired by bradykinin. This is where our project starts.