GSK3β Inhibition Ameliorates Atherosclerotic Calcification.

Xinjiang Cai,Yan Zhao, Yang Yang,Xiuju Wu,Li Zhang,Jocelyn A Ma,Jaden Ji,Kristina I Boström,Yucheng Yao

International Journal of Molecular Sciences（2023）

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摘要

Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to atherosclerotic calcification. In a previous study, we showed that glycogen synthase kinase-3β (GSK3β) inhibition induced β-catenin and reduced mothers against DPP homolog 1 (SMAD1) in order to redirect osteoblast-like cells towards endothelial lineage, thereby reducing vascular calcification in Matrix Gla Protein (Mgp)Ins2Akita/wtApoe-/-Mgp-/-Mgp-/-

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