Cyclosporine A improves ulcerative colitis complicated with deep vein thrombosis with coagulation abnormalities

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon and rectum. UC patients are at increased risk of deep vein thrombosis. Cyclosporine A (CyA) is an immunosuppressant drug that is used to treat severe UC. A 49-year-old man with UC complicated by DVT was treated with CyA. The patient presented with severe bloody diarrhea, lower extremity edema, and a clinical activity index of 16. The patient's coagulation test results were also abnormal. After CyA administration, the patient's leg pain and swelling improved. In addition, the extrinsic coagulation abnormalities improved first after CyA administration, followed by a gradual improvement in the intrinsic coagulation abnormalities. CyA may be effective in correcting coagulation abnormalities that contribute to DVT in UC patients.