Palladium-Catalyzed Enantioselective Indole Allylic Alkylation with Chiral Phosphoramidite-Selenide-Based Ligands

Environmental Engineering Organic Hybrid Functionalized Materials A Pd/phosphoramidite-selenide-catalyzed highly enantioselective C-3 allylic alkylation with a wide range of indole nucleophiles has been developed, giving the corresponding products with up to 95 % yield and 99 % ee. A convenient Pd-catalyzed allylic alkylation of indoles was developed using a P-Se ligand, and the scope of the reaction was demonstrated with various substituted indoles. The corresponding products were obtained in good to excellent yields (up to 95 %) and up to 99 % ee.image