EP02.03-01 ADAR1 Knockout Results in Loss of Tumorigenicity in a Syngeneic Murine Model of Non-small Cell Lung Cancer

B.A. Jacobson, E. Stoian, R. Khadilkar,R.A. Kratzke,M. Patel

Journal of Thoracic Oncology（2023）

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摘要

RNA-editing enzyme, ADAR1 has been implicated in immune regulation of several solid tumors. We aimed to study the effect of ADAR1 loss on NSCLC tumor biology utilizing CRISPR to knockout the ADAR1 gene

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关键词

adar1 knockout results,lung cancer,tumorigenicity,non-small

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