Fabrication of NiSe 2 decorated graphene oxide nanocomposite modified electrode as a high performance electrochemical sensor for carbamazepine

Abstract Recently, semiconductor nanomaterials have gained interest amongst researchers because of their good electrocatalytic properties. Two dimensional (2D) transition metal dichalcogenide materials, NiSe 2 have good physical, chemical, and transport properties for sensing applications. The present work demonstrates the fabrication of NiSe 2 ‐graphene oxide (NiSe 2 −GO) modified glassy carbon electrode for the determination of carbamazepine (CBZ). The prepared nanocomposite was characterized by XRD, SEM and FT‐IR spectral methods. CBZ exhibited an irreversible oxidation peak at 0.85 V on NiSe 2 −GO/GCE in phosphate buffer of pH 7.0. A 54‐fold enhancement in oxidation peak current was observed at NiSe 2 −GO/GCE when compared to that at bare GCE. Sensing performance of NiSe 2 −GO/GCE was optimized by varying peak current dependent parameters. Linear relationship between the peak current and concentration of CBZ was observed in the range of 4.50×10 −8 –3.22×10 −5 mol L −1 for differential pulse voltammetric method and 2.32×10 −8 –4.79×10 −5 mol L −1 for square wave voltammetric method. The practical utility of the proposed sensor, was demonstrated by determining CBZ in pharmaceutical formulations and spiked urine samples.