DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy (Adv. Sci. 19/2023)

Advanced Science(2023)

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摘要
T-Cell Acute Lym-phoblastic Leukemia In article number 2205854, Jingjing Ye, Min Ji, Chunyan Ji, and co-workers observed aberrant adipogenesis in the bone marrow of chemotherapy-treated T-cell acute lymphoblastic leukemia (T-ALL) patients, and the differentiated-adipocytes attract and support residual T-ALL cells. Last, an SREBF1 inhibitor demonstrates superior improvement on therapeutic effect of dexamethason by reducing adipogenesis and provides a feasible strategy to solve the dilemma of recurrence.
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srebf1 promotes,adipocytes,acute lymphoblastic leukemia
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