Synthesis of ethyl 4-(2-fluoro-4-nitrophenoxy) picolinate

Cancer has seriously affected people's production and life. The appearance of anti-cancer drugs has brought good news to people. Ethyl 4-(2-fluoro-4-nitrophenoxy) picolinate is an important basic skeleton of a small molecule inhibitor of c-Met and a major intermediate in cancer therapy. A rapid and efficient method for the synthesis of compound 8 was established. Compound 8 was synthesized from picolinic acid by acylation and substitution. These steps were weight gain reaction. The synthesis method was optimized and the structure was confirmed by hydrogen NMR spectroscopy.