Cross-omic analysis highlights epigenetic setpoints following a polyphenol-rich diet: DIRECT PLUS trial

Anne Hoffmann,Anat Yaskolka Meir,Tobias Hagemann,Luise Müller,Beatrice Engelmann,Sven-Bastiaan Haange,Ulrike Rolle-Kampczyk,Gal Tsaban,Hila Zelicha,Ehud Rinott,Alon Kaplan, Ilan Shelef,Michael Stümvoll,Matthias Blüher,Liming Liang,Uta Ceglarek,Berend Isermann,Martin von Bergen, Péter Kempler,Maria Keller,Iris Shai

Diabetologie Und Stoffwechsel（2023）

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摘要

Background To highlight molecular mechanisms underlying the beneficial metabolic effects of a Mediterranean (MED) diet enriched in polyphenols and reduced in red/processed meat (greenMED), we analyzed its effects on methylome and transcriptome in the 18-month DIRECT PLUS randomized controlled trial.

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epigenetic setpoints,diet,cross-omic,polyphenol-rich

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