MRI Parameters of 3D FLAIR T2 Imaging Technique for Visualization of the Brain Lymphatic Signals

Abstract Meningeal lymphatic vessels (MLVs) have been described in animal studies, but limited comparable data is available in human studies. Non-contrast 3D T2-Fluid Attenuated Inversion Recovery (FLAIR) magnetic resonance imaging relies on protein-rich lymphatic fluid internal signals rather than contrast media. Here, we outline our non-contrast 3D FLAIR MR method permitting visualization of dorsal-along the venous sinuses and ventral lymphatic structures-flow around perineural/peridural spaces of cranial nerves, cerebrospinal fluid (CSF) - interstitial fluid (ISF) drainage around nerves in the human brain in detail.