Contact lens disinfectants against Acanthamoeba keratitis: an overview of recent patents and future needs

Pharmaceutical Patent AnalystAhead of Print EditorialContact lens disinfectants against Acanthamoeba keratitis: an overview of recent patents and future needsRuqaiyyah Siddiqui & Naveed A KhanRuqaiyyah SiddiquiCollege of Arts & Sciences, American University of Sharjah, University City, Sharjah, 26666, United Arab EmiratesMicrobiota Research Center, Istinye University, Istanbul, 34010, TurkeySearch for more papers by this author & Naveed A Khan *Author for correspondence: E-mail Address: naveed5438@gmail.comhttps://orcid.org/0000-0001-7667-8553Microbiota Research Center, Istinye University, Istanbul, 34010, TurkeySearch for more papers by this authorPublished Online:31 Aug 2023https://doi.org/10.4155/ppa-2023-0012AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: contact lens disinfectantseye infectionkeratitisparasitesReferences1. Contact Lenses Market Research Report. Market Research Future (2021). https://www.marketresearchfuture.com/reports/contact-lenses-market/tocGoogle Scholar2. Siddiqui R, Khan NA. Current strategies to treat Acanthamoeba keratitis: a patent overview. Pharm. Pat. Anal. 9(5), 135–137 (2020).Link, CAS, Google Scholar3. Khan SA, Lee CS. Recent progress and strategies to develop antimicrobial contact lenses and lens cases for different types of microbial keratitis. Acta Biomaterialia 113, 101–118 (2020).Crossref, CAS, Google Scholar4. Khan NA, Anwar A, Siddiqui R. Acanthamoeba keratitis: current status and urgent research priorities. Curr. Med. Chem. 26(30), 5711–5726 (2019).Crossref, Medline, CAS, Google Scholar5. Xiao A, Dhand C, Leung CM, Beuerman RW, Ramakrishna S, Lakshminarayanan R. Strategies to design antimicrobial contact lenses and contact lens cases. J. Mater. Chem. B 6(15), 2171–2186 (2018).Crossref, Medline, CAS, Google Scholar6. Tu EY, Joslin CE. Recent outbreaks of atypical contact lens-related keratitis: what have we learned? Am. J. Ophthalmol. 150(5), 602–608 (2010).Crossref, Google Scholar7. Tu EY, Joslin CE. Recent outbreaks of atypical contact lens-related keratitis: what have we learned? Am. J. Ophthalmol. 150(5), 602–608 (2010).Crossref, Google Scholar8. Kaufman AR, Tu EY. Advances in the management of Acanthamoeba keratitis: a review of the literature and synthesized algorithmic approach. Ocul. Surf. 25, 26–36 (2022).Crossref, Google Scholar9. Abjani F, Khan NA, Jung SY, Siddiqui R. Status of the effectiveness of contact lens disinfectants in Malaysia against keratitis-causing pathogens. Exp. Parasitol. 183, 187–193 (2017).Crossref, Medline, CAS, Google Scholar10. Lakhundi S, Khan NA, Siddiqui R. Inefficacy of marketed contact lens disinfection solutions against keratitis-causing Acanthamoeba castellanii belonging to the T4 genotype. Exp. Parasitol. 141, 122–8 (2014).Crossref, Medline, CAS, Google Scholar11. Siddiqui R, Lakhundi S, Khan NA. Status of the effectiveness of contact lens solutions against keratitis-causing pathogens. Contact Lens and Anterior Eye 38(1), 34–38 (2015).Crossref, Medline, Google Scholar12. Abjani F, Khan NA, Yousuf FA, Siddiqui R. Targeting cyst wall is an effective strategy in improving the efficacy of marketed contact lens disinfecting solutions against Acanthamoeba castellanii cysts. Contact Lens and Anterior Eye 39 (3), 239–243 (2013).Crossref, Google Scholar13. Verani JR, Lorick SA, Yoder JS et al. National outbreak of Acanthamoeba keratitis associated with use of a contact lens solution, United States. Emerg. Infect. Dis. 15(8), 1236 (2009).Crossref, Google Scholar14. Szczotka-Flynn L, Ahearn DG, Barr J et al. History, evolution, and evolving standards of contact lens care. Contact Lens and Anterior Eye 36, S4–S8 (2013).Crossref, Google Scholar15. International Organization for Standardization (ISO)International Standard ISO 19045:2015. Ophthalmic optics – contact lens care products – method for evaluating acanthamoeba encystment by contact lens care products. https://www.iso.org/standard/63807.htmlGoogle Scholar16. International Organization for Standardization (ISO)International Standard ISO/DIS 19045-2. Ophthalmic optics – contact lens care products – Part 2: method for evaluating disinfecting efficacy by contact lens care products using trophozoites of Acanthamoeba species as the challenge organisms [Under development]. https://www.iso.org/standard/83822.htmlGoogle Scholar17. Siddiqui R, Makhlouf Z, Akbar N et al. Antiamoebic properties of salicylic acid-based deep eutectic solvents for the development of contact lens disinfecting solutions against Acanthamoeba. Mol. Biochem. Parasitol. 250, 111493 (2022).Crossref, CAS, Google Scholar18. Akbar N, Siddiqui R, Khamis M, Ibrahim T, Khan NA. A novel montmorillonite clay-cetylpyridinium chloride complex as a potential antiamoebic composite material in contact lenses disinfection. Exp. Parasitol. 240, 108330 (2022).Crossref, CAS, Google Scholar19. Siddiqui R, Shah RA, Akbar N et al. Antibacterial effects of octadecyl trimethylammonium micelle–clay complex against bacterial eye pathogens: potential as a contact lens disinfectant. Int. Ophthalmol. 42(3), 939–944 (2022).Crossref, Google Scholar20. Bausch and Lomb Inc. US20190038795A1 (2019).Google Scholar21. Menicon Co Ltd. US11331404B2 (2020).Google Scholar22. Administrators of the Tulane Educational Fund. US20190224361A1 (2019).Google Scholar23. Anwar A, Khan NA, Siddiqui R. Combating Acanthamoeba spp. cysts: what are the options?. Parasites & Vectors 11(1), 1–6 (2018).Crossref, Google Scholar24. Georgia State University Research Foundation Inc. US20220096441A1 (2019).Google Scholar25. Johnson and Johnson Vision Care Inc. US9833535B2 (2015).Google Scholar26. Cope JR, Collier SA, Rao MM et al. Contact lens wearer demographics and risk behaviors for contact lens-related eye infections – United States, 2014. Morbi. Mortal. Weekly Rep. 64(32), 865 (2015).Crossref, Google ScholarFiguresReferencesRelatedDetails Ahead of Print STAY CONNECTED Metrics Downloaded 0 times History Received 2 March 2023 Accepted 9 March 2023 Published online 31 August 2023 Information© 2023 Newlands PressKeywordscontact lens disinfectantseye infectionkeratitisparasitesFinancial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download