Experimental precision medicine: Mouse models in which to test precision medicine

We require experimental populations in which to test precision medicine interventions before they can be translated to humans. Mouse models can provide immortal genometypes that can be resampled at any stage, in either sex, and under any experimental conditions to model genome-by-environment interactions and test genome-phenome predictions. This allows for experimental precision medicine—systems in which causal models of complex interactions among DNA variants, phenotype variation at many levels, and innumerable environmental factors can be built. In this chapter, I review some of the challenges of precision medicine and how mouse populations can overcome these challenges. Lastly, I provide specific suggestions and tools for future development of experimental precision medicine.