Primordial odontogenic tumor – Report of two cases and review of current concepts

Abstract Primordial odontogenic tumor (POT) is a rare mixed odontogenic tumor composed of mesenchymal cells, columnar odontogenic epithelium, and fibromyxoid stroma affecting the posterior mandible of children and adolescents. Herein, we report two cases of POT and the clinicopathological features of previous cases reported in the literature. A 12-year-old and 19-year-old female patient presented an asymptomatic swelling in the posterior maxilla and posterior mandible, respectively. Imaging exams revealed radiolucent lesions associated with uneruptedteeth. The lesions were surgically removed, and the histopathological examination revealed spindle-to-ovoid mesenchymal cells in a fibromyxoid stroma surfaced by columnar odontogenic epithelial cells with reverse nuclear polarization. Deposition of mineralized tissue was observed. The final diagnosis was POT, and patients do not exhibit recurrence signs. POT should be included in the differential diagnoses of intraosseous lesions in the posterior mandible in pediatric patients.